产品货号：
Z20481
中文名称：
MEKK3/MAP3K3抗体
英文名称：
Anti-MEKK3/MAP3K3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MEKK3/MAP3K3 Antibody |
| 指标别名 | MAP3K3;MAPK/ERK kinase kinase 3;MAPKKK3;MEK kinase 3;MEKK 3;MEKK3 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | MAP3K3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human MEKK3(11-25aa MNDLVALQMNRRHRM). |
| 实际分子量 | 71KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MAP3K3(Mitogen-activated protein kinase kinase kinase 3),also known as MAP/ERK KINASE KINASE 3,MEKK3 or MAPKKK3,is an enzyme that in humans is encoded by the MAP3K3 gene.MAP3K3 is contiguously distal to LYK5 on chromosome 17(Puffenberger et al.,2007).By yeast 2-hybrid analysis of a mouse T-cell cDNA library,Uhlik et al.(2003) showed that a C-terminal fragment of mouse Osm(CCM2) interacted with Mekk3,which activates p38 in response to sorbitol-induced hyperosmotic conditions.Mekk3 and Osm colocalized in the cytoplasmic compartment of cotransfected cells,and the Mekk3-Osm complex was recruited to Rac1 and cytoskeletal actin-containing membrane ruffles in response to sorbitol treatment.Protein interaction assays showed that Osm interacted directly with the Mekk3 substrate Mkk3(MAP2K3),with actin,and with both GDP- and GTP-loaded Rac1.Uhlik et al.(2003) concluded that the RAC1-OSM-MEKK3-MKK3 complex is required for regulation of p38 activity in response to osmotic shock. |
| Uniprot ID | Q99759 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | mitogen-activated protein kinase kinase kinase 3 |
| 蛋白名全称 | Mitogen-activated protein kinase kinase kinase 3 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
相关搜索：MEKK3/MAP3K3抗体，MEKK3抗体，MAP3K3多抗，Anti-MEKK3/MAP3K3 Antibody